Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial diabetes in mice expressing a dominant-negative allele of nuclear respiratory factor-1 (Nrf1) in pancreatic β-cells.

Biochemical and biophysical research communications - 10 Dec 2024

Morrish Fionnuala, Gingras Helene, Noonan Joanna, Huang Li, Sweet Ian R, Kuok Iok Teng, Knoblaugh Sue E, Hockenbery David M

Abstract excerpt

Genetic polymorphisms in nuclear respiratory factor-1 (Nrf1), a key transcriptional regulator of nuclear-encoded mitochondrial proteins, have been linked to diabetes. Homozygous deletion of Nrf1 is embryonic lethal in mice. Our goal was to generate mice with β-cell-specific reduction in NRF1 function to investigate the relationship between NRF1 and diabetes. We report the generation of mice expressing a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Diabetes Mellitus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Insulin

Share to Insulin-Secreting Cells

Share to Mice, Transgenic

Share to Mitochondria

Source

Identifiers

PMID: 39128225
DOI: 10.1016/j.bbrc.2024.150478

Genes

NRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial diabetes in mice expressing a dominant-negative allele of nuclear respiratory factor-1 (Nrf1) in pancreatic β-cells.PMID 39128225Read ↗

Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure.Semantic proximity Read ↗

Nrf2 Regulates β-cell Mass by Suppressing Cell Death and Promoting ProliferationSemantic proximity Read ↗

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.Semantic proximity Read ↗

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.Semantic proximity Read ↗

Mitochondrial dysfunction and pancreatic islet β‑cell failure (Review)Semantic proximity Read ↗

Mitofusins <i>Mfn1</i> and <i>Mfn2</i> are required to preserve glucose-but not incretin- stimulated beta cell connectivity and insulin secretionSemantic proximity Read ↗

Autophagy Inhibition Enables Nrf2 to Exaggerate the Progression of Diabetic Cardiomyopathy in MiceSemantic proximity Read ↗

Mitoribosome insufficiency in β cells is associated with type 2 diabetes-like islet failureSemantic proximity Read ↗

Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice.Semantic proximity Read ↗

Failure to Repair Endogenous DNA Damage in β-Cells Causes Adult-Onset Diabetes in MiceSemantic proximity Read ↗

Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets.Semantic proximity Read ↗

Mitochondrial and protein homeostasis pathways are transcriptionally impaired in islets during type 1 diabetes pathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.