Article
Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy.
Molecular and cellular biology - 1 Dec 2005
Joza Nicholas, Oudit Gavin Y, Brown Doris, Bénit Paule, Kassiri Zamaneh, Vahsen Nicola, Benoit Loralyn, Patel Mikin M, Nowikovsky Karin, Vassault Anne, Backx Peter H, Wada Teiji, Kroemer Guido, Rustin Pierre, Penninger Josef M
Abstract excerpt
Cardiac and skeletal muscle critically depend on mitochondrial energy metabolism for their normal function. Recently, we showed that apoptosis-inducing factor (AIF), a mitochondrial protein implicated in programmed cell death, plays a role in mitochondrial respiration. However, the in vivo consequences of AIF-regulated mitochondrial respiration resulting from a loss-of-function mutation in Aif are not known....
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