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Article

Muscle expression of a malonyl-CoA-insensitive carnitine palmitoyltransferase-1 protects mice against high-fat/high-sucrose diet-induced insulin resistance.

American journal of physiology. Endocrinology and metabolism - 1 Sept 2016

Vavrova Eliska, Lenoir Véronique, Alves-Guerra Marie-Clotilde, Denis Raphaël G, Castel Julien, Esnous Catherine, Dyck Jason R B, Luquet Serge, Metzger Daniel, Bouillaud Frédéric, Prip-Buus Carina

Abstract excerpt

Impaired skeletal muscle mitochondrial fatty acid oxidation (mFAO) has been implicated in the etiology of insulin resistance. Carnitine palmitoyltransferase-1 (CPT1) is a key regulatory enzyme of mFAO whose activity is inhibited by malonyl-CoA, a lipogenic intermediate. Whereas increasing CPT1 activity in vitro has been shown to exert a protective effect against lipid-induced insulin resistance in skeletal muscle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27507552
DOI: 10.1152/ajpendo.00020.2016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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