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Article

FoxO1 Deacetylation Decreases Fatty Acid Oxidation in β-Cells and Sustains Insulin Secretion in Diabetes.

The Journal of biological chemistry - 6 May 2016

Kim-Muller Ja Young, Kim Young Jung R, Fan Jason, Zhao Shangang, Banks Alexander S, Prentki Marc, Accili Domenico

Abstract excerpt

Pancreatic β-cell dysfunction contributes to onset and progression of type 2 diabetes. In this state β-cells become metabolically inflexible, losing the ability to select between carbohydrates and lipids as substrates for mitochondrial oxidation. These changes lead to β-cell dedifferentiation. We have proposed that FoxO proteins are activated through deacetylation-dependent nuclear translocation to forestall the...

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Share to Acetylation
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Acids

Share to Forkhead Box Protein O1

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Share to Insulin-Secreting Cells

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Source

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Identifiers

PMID: 26984405
DOI: 10.1074/jbc.M115.705608
PMCID: PMC4858967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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