Article
Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis.
Diabetes - 1 Apr 2016
Coughlan Melinda T, Higgins Gavin C, Nguyen Tuong-Vi, Penfold Sally A, Thallas-Bonke Vicki, Tan Sih Min, Ramm Georg, Van Bergen Nicole J, Henstridge Darren C, Sourris Karly C, Harcourt Brooke E, Trounce Ian A, Robb Portia M, Laskowski Adrienne, McGee Sean L, Genders Amanda J, Walder Ken, Drew Brian G, Gregorevic Paul, Qian Hongwei, Thomas Merlin C, Jerums George, Macisaac Richard J, Skene Alison, Power David A, Ekinci Elif I, Wijeyeratne Xiaonan W, Gallo Linda A, Herman-Edelstein Michal, Ryan Michael T, Cooper Mark E, Thorburn David R, Forbes Josephine M
Abstract excerpt
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein with dual roles in redox signaling and programmed cell death. Deficiency in AIF is known to result in defective oxidative phosphorylation (OXPHOS), via loss of complex I activity and assembly in other tissues. Because the kidney relies on OXPHOS for metabolic homeostasis, we hypothesized that a decrease in AIF would result in chronic kidney disease...
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