Article
Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.
Nature genetics - 1 Oct 2002
Nakae Jun, Biggs William H, Kitamura Tadahiro, Cavenee Webster K, Wright Christopher V E, Arden Karen C, Accili Domenico
Abstract excerpt
Type 2 diabetes results from impaired action and secretion of insulin. It is not known whether the two defects share a common pathogenesis. We show that haploinsufficiency of the Foxo1 gene, encoding a forkhead transcription factor (forkhead box transcription factor O1), restores insulin sensitivity and rescues the diabetic phenotype in insulin-resistant mice by reducing hepatic expression of glucogenetic genes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.