Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Foxo1 integrates insulin signaling with mitochondrial function in the liver.

Nature medicine - 1 Nov 2009

Cheng Zhiyong, Guo Shaodong, Copps Kyle, Dong Xiaochen, Kollipara Ramya, Rodgers Joseph T, Depinho Ronald A, Puigserver Pere, White Morris F

Abstract excerpt

Type 2 diabetes is a complex disease that is marked by the dysfunction of glucose and lipid metabolism. Hepatic insulin resistance is especially pathogenic in type 2 diabetes, as it dysregulates fasting and postprandial glucose tolerance and promotes systemic dyslipidemia and nonalcoholic fatty liver disease. Mitochondrial dysfunction is closely associated with insulin resistance and might contribute to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electron Transport Chain Complex Proteins
Share to Forkhead Box Protein O1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heme Oxygenase-1

Share to Hepatocytes

Share to Insulin Receptor Substrate Proteins

Share to Membrane Potential, Mitochondrial

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 19838201
DOI: 10.1038/nm.2049
PMCID: PMC3994712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Foxo1 integrates insulin signaling with mitochondrial function in the liver.PMID 19838201Read ↗

Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.Semantic proximity Read ↗

FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue.Semantic proximity Read ↗

A Review of FoxO1-Regulated Metabolic Diseases and Related Drug DiscoveriesSemantic proximity Read ↗

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.Semantic proximity Read ↗

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.Semantic proximity Read ↗

FoxO integration of insulin signaling with glucose and lipid metabolism.Semantic proximity Read ↗

Non-enzymatic ABHD6 interacts with Akt-FoxO1 axis to regulate selective hepatic insulin resistanceSemantic proximity Read ↗

Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.Semantic proximity Read ↗

Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again.Semantic proximity Read ↗

Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: An <i>in vivo</i> analysis in MIRKO miceSemantic proximity Read ↗

A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism.Semantic proximity Read ↗

Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.