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Article

Foxo1 integrates insulin signaling with mitochondrial function in the liver.

Nature medicine - 1 Nov 2009

Cheng Zhiyong, Guo Shaodong, Copps Kyle, Dong Xiaochen, Kollipara Ramya, Rodgers Joseph T, Depinho Ronald A, Puigserver Pere, White Morris F

Abstract excerpt

Type 2 diabetes is a complex disease that is marked by the dysfunction of glucose and lipid metabolism. Hepatic insulin resistance is especially pathogenic in type 2 diabetes, as it dysregulates fasting and postprandial glucose tolerance and promotes systemic dyslipidemia and nonalcoholic fatty l...

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Share to Electron Transport Chain Complex Proteins
Share to Forkhead Box Protein O1
Share to Heme Oxygenase-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocytes

Share to Insulin Receptor Substrate Proteins

Share to Membrane Potential, Mitochondrial

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Source

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Identifiers

PMID: 19838201
DOI: 10.1038/nm.2049
PMCID: PMC3994712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19838201-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Foxo1 integrates insulin signaling with mitochondrial function in the liver.PMID 19838201Read ↗

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A mutant allele encoding DNA binding-deficient FoxO1 differentially regulates hepatic glucose and lipid metabolism.Semantic proximity Read ↗

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