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Article

The COMT val158met polymorphism is associated with prevalent fractures in Swedish men.

Bone - 1 Jan 2008

Eriksson Anna L, Mellström Dan, Lorentzon Mattias, Orwoll Eric S, Redlund-Johnell Inga, Grundberg Elin, Holmberg Anna, Ljunggren Osten, Karlsson Magnus K, Ohlsson Claes

Abstract excerpt

INTRODUCTION: Sex steroids are important for growth and maintenance of the skeleton. Catechol-O-methyltransferase (COMT) is an estrogen degrading enzyme. The COMT val158met polymorphism results in a 60-75% difference in enzyme activity between the val (high activity=H) and met (low activity=L) variants. We have previously reported that this polymorphism is associated with bone mineral density (BMD) in young men....

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Source

Identifiers

PMID: 17962094
DOI: 10.1016/j.bone.2007.08.045

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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