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Article

The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men.

The Journal of clinical endocrinology and metabolism - 1 Aug 2007

Stolk Lisette, van Meurs Joyce B J, Jhamai Mila, Arp Pascal P, van Leeuwen Johannes P T, Hofman Albert, de Jong Frank H, Pols Huibert A P, Uitterlinden André G

Abstract excerpt

CONTEXT: Because sex steroids play an important role in bone development, variants in genes encoding proteins involved in estrogen synthesis and metabolism could contribute to interindividual variation in bone parameters and fracture risk. An example is catechol-O-methyltransferase (COMT), an estrogen-degrading enzyme involved in inactivation of catechol-estrogens. Its gene contains a functional valine to...

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Source

Identifiers

PMID: 17504906
DOI: 10.1210/jc.2006-2136

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men.PMID 17504906Read ↗

The COMT val158met polymorphism is associated with prevalent fractures in Swedish men.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT) Val158Met polymorphism and risk of osteoporotic fracture.Semantic proximity Read ↗

The COMT val158met polymorphism is associated with peak BMD in men.Semantic proximity Read ↗

Estrogen metabolizing polymorphisms and breast cancer risk among older white women.Semantic proximity Read ↗

Association between physical activity and BMD in young men is modulated by catechol-O-methyltransferase (COMT) genotype: the GOOD study.Semantic proximity Read ↗

Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men.Semantic proximity Read ↗

Influence of the catechol-O-methyltransferase (COMT) codon 158 polymorphism on estrogen levels in women.Semantic proximity Read ↗

Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria.Semantic proximity Read ↗

An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.Semantic proximity Read ↗

Polymorphisms in CYP17, COMT, and ESR1 genes in women after menopause and association with bone mineral density.Semantic proximity Read ↗

Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.Semantic proximity Read ↗

A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain.Semantic proximity Read ↗

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