Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The COMT val158met polymorphism is associated with early pubertal development, height and cortical bone mass in girls.

Pediatric research - 1 Jul 2005

Eriksson Anna-Lena, Suuriniemi Miia, Mahonen Anitta, Cheng Sulin, Ohlsson Claes

Abstract excerpt

Estrogens are involved in accretion of bone mass during puberty. Catechol-O-Methyltransferase (COMT) is involved in the degradation of estrogens. In this cross-sectional study we investigated associations between the COMT val158met polymorphism, which results in a 60-75% difference in enzyme activity between the val (high activity = H) and the met (low activity = L) variant, and skeletal phenotypes in 246 healthy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Absorptiometry, Photon
Share to Body Composition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Height

Share to Catechol O-Methyltransferase

Share to Estradiol

Share to Estrogens

Share to Methionine

Share to Puberty

Source

Identifiers

PMID: 15985686
DOI: 10.1203/01.PDR.0000163383.49747.B5

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The COMT val158met polymorphism is associated with early pubertal development, height and cortical bone mass in girls.PMID 15985686Read ↗

The COMT val158met polymorphism is associated with peak BMD in men.Semantic proximity Read ↗

Association between physical activity and BMD in young men is modulated by catechol-O-methyltransferase (COMT) genotype: the GOOD study.Semantic proximity Read ↗

The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.Semantic proximity Read ↗

Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men.Semantic proximity Read ↗

Adolescence is the starting point of sex-dichotomous COMT genetic effects.Semantic proximity Read ↗

The catechol-O-methyltransferase gene: its regulation and polymorphisms.Semantic proximity Read ↗

Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children.Semantic proximity Read ↗

The COMT val158met polymorphism is associated with prevalent fractures in Swedish men.Semantic proximity Read ↗

Met158 variant of the catechol-O-methyltransferase genotype is associated with thicker cortex in adult brain.Semantic proximity Read ↗

Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.Semantic proximity Read ↗

Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders.Semantic proximity Read ↗

Polymorphisms in CYP17, COMT, and ESR1 genes in women after menopause and association with bone mineral density.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.