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Article

A single bottleneck in HLA-C assembly.

The Journal of biological chemistry - 18 Jan 2008

Sibilio Leonardo, Martayan Aline, Setini Andrea, Monaco Elisa Lo, Tremante Elisa, Butler Richard H, Giacomini Patrizio

Abstract excerpt

Poor assembly of class I major histocompatibility HLA-C heavy chains results in their intracellular accumulation in two forms: free of and associated with their light chain subunit (beta(2)-microglobulin). Both intermediates are retained in the endoplasmic reticulum by promiscuous and HLA-dedicated chaperones and are poorly associated with peptide antigens. In this study, the eight serologically defined HLA-C...

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Identifiers

PMID: 17956861
DOI: 10.1074/jbc.M708068200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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