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The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding

22 Jun 2010

Abstract excerpt

Major histocompatibility complex class I (MHC I) proteins protect the host from intracellular pathogens and cellular abnormalities through the binding of peptide fragments derived primarily from intracellular proteins. These peptide-MHC complexes are displayed at the cell surface for inspection by cytotoxic T lymphocytes. Here we reveal how MHC I molecules achieve this feat in the face of numerous levels of...

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PMID: 21050182
DOI: 10.1111/j.1399-0039.2010.01550.x

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