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Article

Distinct mechanisms survey the structural integrity of HLA-B*27:05 intracellularly and at the surface.

PloS one - 1 Jan 2018

Hein Zeynep, Borchert Britta, Abualrous Esam Tolba, Springer Sebastian

Abstract excerpt

HLA-B*27:05 is associated with the development of autoimmune spondyloarthropathies, but the precise causal relationship between the MHC haplotype and disease pathogenesis is yet to be elucidated. Studies focusing on the structure and cellular trafficking of HLA-B*27:05 implicate several links between the onset of inflammation and the unusual conformations of the molecule inside and at the surface of antigen...

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Identifiers

PMID: 30071035
DOI: 10.1371/journal.pone.0200811
PMCID: PMC6071996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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