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Article

Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity.

eLife - 10 Jul 2018

Yarzabek Brogan, Zaitouna Anita J, Olson Eli, Silva Gayathri N, Geng Jie, Geretz Aviva, Thomas Rasmi, Krishnakumar Sujatha, Ramon Daniel S, Raghavan Malini

Abstract excerpt

The highly polymorphic human leukocyte antigen (HLA) class I molecules present peptide antigens to CD8+ T cells, inducing immunity against infections and cancers. Quality control mediated by peptide loading complex (PLC) components is expected to ensure the cell surface expression of stable peptide-HLA class I complexes. This is exemplified by HLA-B*08:01 in primary human lymphocytes, with both expression level...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29989547
DOI: 10.7554/eLife.34961
PMCID: PMC6039183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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