Article

Endo-lysosomal assembly variations among Human Leukocyte Antigen class I (HLA-I) allotypes

2022-04-01

Abstract excerpt

The extreme polymorphisms of HLA-I proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes (CTL). The canonical endoplasmic reticulum (ER) HLA-I assembly pathway enables presentation of cytosolic peptides, but effective intracellular surveillance requires multi-compartmental antigen sampling. Endo-lysosomes are generally sites of HLA class II assembly, but human monocytes and monocyte-deriv...

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Literature Corpus work: 5aa33242-29e1-5237-891d-71d2b21bf2f5
DOI: 10.1101/2022.03.31.485520

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