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Article

Productive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain.

Molecular immunology - 1 Jan 2012

Simone Laura C, Georgesen Corey J, Simone Peter D, Wang Xiaojian, Solheim Joyce C

Abstract excerpt

The current model of antigen assembly with major histocompatibility complex (MHC) class I molecules posits that interactions between the tapasin N-terminal immunoglobulin (Ig)-like domain and the MHC class I peptide-binding groove permit tapasin to regulate antigen selection. Much less is known regarding interactions that might involve the tapasin C-terminal Ig-like domain. Additionally, the tapasin...

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Identifiers

PMID: 22169163
DOI: 10.1016/j.molimm.2011.11.002
PMCID: PMC3249531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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