Article

A Chicken Tapasin ortholog can chaperone empty HLA molecules independently of other peptide-loading components

2023-06-26

Abstract excerpt

Human Tapasin (hTapasin) is the main chaperone of MHC-I molecules, enabling peptide loading and antigen repertoire optimization across HLA allotypes. However, it is restricted to the endoplasmic reticulum (ER) lumen as part of the protein loading complex (PLC) and therefore is highly unstable when expressed in recombinant form. Additional stabilizing co-factors such as ERp57 are required to catalyze peptide exchan...

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Literature Corpus work: 20844e45-169a-5b1b-b15a-f6d430fcf925
DOI: 10.1101/2023.06.23.546255

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