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Article

Stability and Expression Levels of HLA-C on the Cell Membrane Modulate HIV-1 Infectivity.

Journal of virology - 1 Jan 2018

Parolini Francesca, Biswas Priscilla, Serena Michela, Sironi Francesca, Muraro Valentina, Guizzardi Elisabetta, Cazzoletti Lucia, Scupoli Maria Teresa, Gibellini Davide, Ugolotti Elisabetta, Biassoni Roberto, Beretta Alberto, Malnati Mauro, Romanelli Maria Grazia, Zipeto Donato

Abstract excerpt

HLA-C expression is associated with a differential ability to control HIV-1 infection. Higher HLA-C levels may lead to better control of HIV-1 infection through both a higher efficiency of antigen presentation to cytotoxic T lymphocytes and the triggering of activating killer immunoglobulin-like receptors on NK cells, whereas lower levels may provide poor HIV-1 control and rapid progression to AIDS. We...

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Share to Antigen Presentation
Share to beta 2-Microglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Donors

Share to Histocompatibility Antigens Class I

Share to HLA-C Antigens

Share to Killer Cells, Natural

Share to Leukocytes, Mononuclear

Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 29070683
DOI: 10.1128/JVI.01711-17
PMCID: PMC5730790

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