Article
Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503.
Immunogenetics - 1 Dec 2009
Thammavongsa Vilasack, Schaefer Malinda, Filzen Tracey, Collins Kathleen L, Carrington Mary, Bangia Naveen, Raghavan Malini
Abstract excerpt
Residue 116 of major histocompatibility complex (MHC) class I heavy chains is an important determinant of assembly, that can influence rates of ER-Golgi trafficking, binding to the transporter associated with antigen processing (TAP), tapasin dependence of assembly, and the efficiency and specificity of peptide binding. Here, we investigated assembly and peptide-binding differences between HLA-B*3501(S116) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
