Article
Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503.
Immunogenetics - 1 Dec 2009
Thammavongsa Vilasack, Schaefer Malinda, Filzen Tracey, Collins Kathleen L, Carrington Mary, Bangia Naveen, Raghavan Malini
Abstract excerpt
Residue 116 of major histocompatibility complex (MHC) class I heavy chains is an important determinant of assembly, that can influence rates of ER-Golgi trafficking, binding to the transporter associated with antigen processing (TAP), tapasin dependence of assembly, and the efficiency and specificity of peptide binding. Here, we investigated assembly and peptide-binding differences between HLA-B*3501(S116) and...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP-Binding Cassette Transporters
- Acquired Immunodeficiency Syndrome
- Alleles
- Baculoviridae
- CD4-Positive T-Lymphocytes
- Cell Line
- Disease Progression
- Endoplasmic Reticulum
- Genetic Vectors
- Golgi Apparatus
- HIV
- HIV Infections