Article
Diversity of natural self-derived ligands presented by different HLA class I molecules in transporter antigen processing-deficient cells.
PloS one - 1 Jan 2013
Lorente Elena, Infantes Susana, Barnea Eilon, Beer Ilan, Barriga Alejandro, García-Medel Noel, Lasala Fátima, Jiménez Mercedes, Admon Arie, López Daniel
Abstract excerpt
The transporter associated with antigen processing (TAP) translocates the cytosol-derived proteolytic peptides to the endoplasmic reticulum lumen where they complex with nascent human leukocyte antigen (HLA) class I molecules. Non-functional TAP complexes and viral or tumoral blocking of these transporters leads to reduced HLA class I surface expression and a drastic change in the available peptide repertoire....
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