Article
Effect of 17q21 variants and smoking exposure in early-onset asthma.
The New England journal of medicine - 6 Nov 2008
Bouzigon Emmanuelle, Corda Eve, Aschard Hugues, Dizier Marie-Hélène, Boland Anne, Bousquet Jean, Chateigner Nicolas, Gormand Frédéric, Just Jocelyne, Le Moual Nicole, Scheinmann Pierre, Siroux Valérie, Vervloet Daniel, Zelenika Diana, Pin Isabelle, Kauffmann Francine, Lathrop Mark, Demenais Florence
Abstract excerpt
BACKGROUND: A genomewide association study has shown an association between variants at chromosome 17q21 and an increased risk of asthma. To elucidate the relationship between this locus and disease, we examined a large, family-based data set that included extensive phenotypic and environmental data from the Epidemiological Study on the Genetics and Environment of Asthma. METHODS: We tested 36 single-nucleotide...
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