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Article

TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids.

Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2004

Tantisira Kelan G, Hwang Eun Sook, Raby Benjamin A, Silverman Eric S, Lake Stephen L, Richter Brent G, Peng Stanford L, Drazen Jeffrey M, Glimcher Laurie H, Weiss Scott T

Abstract excerpt

TBX21 encodes for the transcription factor T-bet (T-box expressed in T cells), which influences naive T lymphocyte development and has been implicated in asthma pathogenesis. Specifically, the T-bet knockout mouse spontaneously develops airway hyperresponsiveness and other changes consistent with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15604153
DOI: 10.1073/pnas.0408532102
PMCID: PMC539815

Genes

TBX21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15604153-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids.PMID 15604153Read ↗

Association analysis of novel TBX21 variants with asthma phenotypes.Semantic proximity Read ↗

T-bet polymorphisms are associated with asthma and airway hyperresponsiveness.Semantic proximity Read ↗

Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.Semantic proximity Read ↗

T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children.Semantic proximity Read ↗

TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants.Semantic proximity Read ↗

Genetic variation in uncontrolled childhood asthma despite ICS treatment.Semantic proximity Read ↗

Genetic variation of TBX21 gene increases risk of asthma and its severity in Indian children.Semantic proximity Read ↗

The TBX21 transcription factor T-1993C polymorphism is associated with decreased IFN-γ and IL-4 production by primary human lymphocytes.Semantic proximity Read ↗

Effect of 17q21 variants and smoking exposure in early-onset asthma.Semantic proximity Read ↗

A common exonic variant of interleukin21 confers susceptibility to atopic asthma.Semantic proximity Read ↗

Association between WDR21A polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients.Semantic proximity Read ↗

Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.Semantic proximity Read ↗

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