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Article

Association between neprilysin polymorphisms and sporadic Alzheimer's disease.

Neuroscience letters - 5 Nov 2007

Wood Linda S, Pickering Eve H, McHale Duncan, Dechairo Bryan M

Abstract excerpt

The deposition of amyloid beta peptide (Abeta) in the form of plaques in the brain is a hallmark of Alzheimer's disease (AD). Neprilysin is the major Abeta-degradating enzyme and reduction in neprilysin activity could contribute to Alzheimer's by increasing the steady-state level of Abeta. To provide further evidence for the role of neprilysin in AD we genotyped 22 polymorphisms, 21 SNPs and the GT repeat in the...

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Source

Identifiers

PMID: 17928142
DOI: 10.1016/j.neulet.2007.09.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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