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Article

Neprilysin Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese.

Molecular neurobiology - 1 Sept 2016

Wang Hui-Zhen, Bi Rui, Zhang Deng-Feng, Li Guo-Dong, Ma Xiao-Hong, Fang Yiru, Li Tao, Zhang Chen, Yao Yong-Gang

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disease, with increasing incidence all over the world. Amyloid-β (Aβ) was considered to be the original cause to AD, and many reported pathogenic or risk genes for AD were located in the Aβ generation and degradation pathways. Neprilysin (NEP), insulin-degrading enzyme (IDE), and matrix metalloprotease-9 (MMP-9) are the most important Aβ-degrading...

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Source

Identifiers

PMID: 26362309
DOI: 10.1007/s12035-015-9411-z

Genes

APP
IDE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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