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Article

Mutation screening and association study of the neprilysin gene in sporadic Alzheimer's disease in Chinese persons.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Mar 2005

Shi Jiajun, Zhang Sizhong, Tang Mouni, Ma Cui, Zhao Jinghua, Li Tao, Liu Xiehe, Sun Yan, Guo Yangbo, Han Haiying, Ma Yongxin, Zhao Zhenhuan

Abstract excerpt

Neprilysin has been reported to be a major beta-amyloid peptide (Abeta)-degrading enzyme. The decreased expression and activity of it may contribute to the development of Alzheimer's disease by promoting the accumulation of Abeta. We used denaturing high-performance liquid chromatography to screen the neprilysin gene (NEP) for single nucleotide polymorphisms (SNPs) in 257 Chinese sporadic Alzheimer's disease...

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Identifiers

PMID: 15860464
DOI: 10.1093/gerona/60.3.301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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