Article
Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2009
Figgins Jessica A, Minster Ryan L, Demirci F Yesim, Dekosky Steven T, Kamboh M Ilyas
Abstract excerpt
Alzheimer's disease (AD) is a complex and multifactorial disease with the possible involvement of several genes. With the exception of the APOE gene as a susceptibility marker, no other genes have been shown consistently to be associated with late-onset AD (LOAD). A recent genome-wide association study of 17,343 gene-based putative functional single nucleotide polymorphisms (SNPs) found 19 significant variants,...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide