Article
Lack of association of neprilysin gene polymorphisms with Alzheimer's disease in a southern Chinese community.
International psychogeriatrics - 1 Apr 2009
Fu Yan, Li Ai Feng, Shi Jia Jun, Tang Mou Ni, Guo Yang Bo, Zhao Zhen Huan
Abstract excerpt
BACKGROUND: Increasing evidence suggests that neprilysin (NEP) may be the major degrading enzyme of amyloid beta (Abeta) in the brain and the NEP gene has been proposed as a candidate gene for Alzheimer's disease (AD). Association results between the NEP gene and AD are still preliminary. This study investigates the effect of the polymorphisms of -204G/C and 159C/T in the NEP gene on the development of sporadic...
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