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Article

Polymorphisms in neprilysin gene affect the risk of Alzheimer's disease in Finnish patients.

Journal of neurology, neurosurgery, and psychiatry - 1 Dec 2004

Helisalmi S, Hiltunen M, Vepsäläinen S, Iivonen S, Mannermaa A, Lehtovirta M, Koivisto A M, Alafuzoff I, Soininen H

Abstract excerpt

OBJECTIVES: Neprilysin (NEP) is an amyloid beta-peptide (Abeta) degrading enzyme expressed in the brain, and accumulation of Abeta is the neuropathological hallmark in Alzheimer's disease (AD). In this study we investigated whether polymorphisms in the NEP gene have an effect on the risk for AD. METHODS: The frequencies of seven single nucleotide polymorphisms (SNPs) and apolipoprotein E (APOE) were assessed in...

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Identifiers

PMID: 15548496
DOI: 10.1136/jnnp.2004.036574
PMCID: PMC1738829

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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