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Article

The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Jun 2025

Morito Takahiro, Hashimoto Shoko, Takamura Risa, Watamura Naoto, Kakiya Naomasa, Fujioka Ryo, Mihara Naomi, Sekiguchi Misaki, Watanabe-Iwata Kaori, Kamano Naoko, Qi Mohan, Matsuba Yukio, Tsubuki Satoshi, Saito Takashi, Iwata Nobuhisa, Sasaguri Hiroki, Saido Takaomi C

Abstract excerpt

An age-dependent decline in the amyloid-β (Aβ)-degrading enzyme neprilysin (NEP) has been implicated in the pathogenesis of sporadic Alzheimer's disease (AD). Recently identified risk alleles in the NEP-coding gene further support its role in AD etiology. However, evidence for the impact of NEP on the pathophysiological progression of Aβ plaque formation, particularly in comparison with another Aβ-degrading...

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Identifiers

PMID: 40300834
DOI: 10.1523/JNEUROSCI.2152-24.2025
PMCID: PMC12139590

Genes

IDE

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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