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Article

Dinucleotide repeat polymorphisms in the neprilysin gene are not associated with sporadic Alzheimer's disease.

Neuroscience letters - 1 Mar 2002

Oda Masaya, Morino Hiroyuki, Maruyama Hirofumi, Terasawa Hideo, Izumi Yuishin, Torii Tsuyoshi, Sasaki Ken, Nakamura Shigenobu, Kawakami Hideshi

Abstract excerpt

In the pathological process of Alzheimer's disease (AD), deposition of amyloid beta-peptide (A beta) in the brain parenchyma plays an important role. Neprilysin (NEP), a neutral endopeptidase, degrades A beta, and it is postulated that decreased NEP activity may contribute to the development of AD by promoting the accumulation of A beta. The human NEP gene possesses four dinucleotide repeat polymorphisms, and it...

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PMID: 11849775
DOI: 10.1016/s0304-3940(02)00057-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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