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Article

Association of the Neprilysin gene with susceptibility to late-onset Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2004

Sakai Ayumu, Ujike Hiroshi, Nakata Kenji, Takehisa Yasushi, Imamura Takaki, Uchida Naohiko, Kanzaki Akihiro, Yamamoto Mitsutoshi, Fujisawa Yoshikatsu, Okumura Kazuya, Kuroda Shigetoshi

Abstract excerpt

Neprilysin (NEP), also known as neutral endopeptidase, enkephalinase, CD 10, and common acute lymphoblastic leukemia antigen, is a 97-kD protein. NEP can degrade amyloid beta peptides, and its mRNA and protein levels are known to be reduced in the brains of patients with Alzheimer's disease (AD), making the NEP gene a substantial candidate for an AD risk factor. We examined the genetic association of three NEP...

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PMID: 14739539
DOI: 10.1159/000076351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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