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Article

Extensive genetic diversity in the Plasmodium falciparum Na+/H+ exchanger 1 transporter protein implicated in quinine resistance.

Antimicrobial agents and chemotherapy - 1 Dec 2007

Vinayak Sumiti, Alam Mohammad Tauqeer, Upadhyay Mala, Das Manoj K, Dev Vas, Singh Neeru, Dash Aditya P, Sharma Yagya D

Abstract excerpt

The Plasmodium falciparum Na(+)/H(+) exchanger (Pfnhe-1) locus at chromosome 13 and another locus at chromosome 9 have recently been proposed to influence quinine resistance. Here, we sequenced the ms4760 locus of the Pfnhe-1 gene from 244 P. falciparum isolates collected from five different regions of India. A total of 16 different ms4760 alleles (with one to five DNNND repeats) were observed among these...

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Identifiers

PMID: 17923493
DOI: 10.1128/AAC.00317-07
PMCID: PMC2167966

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