Polymorphisms in Pfmdr1, Pfcrt, and Pfnhe1 genes are associated with reduced in vitro activities of quinine in Plasmodium falciparum isolates from western Kenya.

doi:10.1128/AAC.02472-14

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Article

Polymorphisms in Pfmdr1, Pfcrt, and Pfnhe1 genes are associated with reduced in vitro activities of quinine in Plasmodium falciparum isolates from western Kenya.

Antimicrobial agents and chemotherapy - 1 Jul 2014

Cheruiyot Jelagat, Ingasia Luicer A, Omondi Angela A, Juma Dennis W, Opot Benjamin H, Ndegwa Joseph M, Mativo Joan, Cheruiyot Agnes C, Yeda Redemptah, Okudo Charles, Muiruri Peninah, Bidii Ngalah S, Chebon Lorna J, Angienda Paul O, Eyase Fredrick L, Johnson Jacob D, Bulimo Wallace D, Andagalu Ben, Akala Hoseah M, Kamau Edwin

Abstract excerpt

In combination with antibiotics, quinine is recommended as the second-line treatment for uncomplicated malaria, an alternative first-line treatment for severe malaria, and for treatment of malaria in the first trimester of pregnancy. Quinine has been shown to have frequent clinical failures, and...

Topics

Alleles
Animals
Antimalarials
DNA, Protozoan
Drug Resistance
Genes, Protozoan
Genotype
Humans
Kenya
Malaria, Falciparum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Transport Proteins

Microsatellite Repeats

Molecular Sequence Data

Multidrug Resistance-Associated Proteins

Parasitic Sensitivity Tests

Plasmodium falciparum

Polymorphism, Genetic

Protozoan Proteins

Source

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Identifiers

PMID: 24752268
DOI: 10.1128/AAC.02472-14
PMCID: PMC4068580

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-24752268-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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