Article
In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger transporter (Pfnhe-1) gene in 393 isolates from Dakar, Senegal.
Malaria journal - 7 Jun 2013
Pascual Aurélie, Fall Bécaye, Wurtz Nathalie, Fall Mansour, Camara Cheikhou, Nakoulima Aminata, Baret Eric, Diatta Bakary, Fall Khadidiatou Ba, Mbaye Pape Saliou, Diémé Yaya, Bercion Raymond, Bogreau Hervé, Briolant Sébastien, Rogier Christophe, Wade Boubacar, Pradines Bruno
Abstract excerpt
BACKGROUND: Although the World Health Organization recommends replacing quinine (QN) by artesunate due to its increased efficacy and the higher tolerance to the drug in both adults and children, QN remains a first-line treatment for severe malaria, especially in Africa. Investigations of microsatellite Pfnhe-1 ms4760 polymorphisms in culture-adapted isolates from around the world have revealed that an increase in...
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