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Article

Quinine treatment selects the pfnhe-1 ms4760-1 polymorphism in Malian patients with Falciparum malaria.

The Journal of infectious diseases - 1 Feb 2013

Kone Aminatou, Mu Jianbing, Maiga Hamma, Beavogui Abdoul H, Yattara Omar, Sagara Issaka, Tekete Mamadou M, Traore Oumar B, Dara Antoine, Dama Souleymane, Diallo Nouhoum, Kodio Aly, Traoré Aliou, Björkman Anders, Gil Jose P, Doumbo Ogobara K, Wellems Thomas E, Djimde Abdoulaye A

Abstract excerpt

BACKGROUND: The mechanism of Plasmodium falciparum resistance to quinine is not known. In vitro quantitative trait loci mapping suggests involvement of a predicted P. falciparum sodium-hydrogen exchanger (pfnhe-1) on chromosome 13. METHODS: We conducted prospective quinine efficacy studies in 2 villages, Kollé and Faladié, Mali. Cases of clinical malaria requiring intravenous therapy were treated with standard...

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Identifiers

PMID: 23162138
DOI: 10.1093/infdis/jis691
PMCID: PMC3537444

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Source receipt: pubmed, retrieved 7 Sept 2026.

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