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Limited Ability ofPlasmodium falciparum pfcrt,pfmdr1, andpfnhe1Polymorphisms To Predict QuinineIn VitroSensitivity or Clinical Effectiveness in Uganda

16 Nov 2010

Abstract excerpt

Quinine is a standard drug for treating severe malaria in Africa, and it is also increasingly used to treat uncomplicated disease. However, failures of quinine therapy are common, and it is unknown if failures in Africa are due to drug resistance. Recent studies have identified associations between in vitro quinine sensitivity and polymorphisms in genes encoding putative transporters, including well-described...

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PMID: 21078941
DOI: 10.1128/aac.00954-10

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