Article
Genetic diversity of Plasmodium falciparum equilibrative nucleoside transporters PfENT1 and PfENT4: Implications for purine-based antimalarial drug development.
International journal for parasitology - 1 Jul 2026
Tashie Worlanyo, de Koning Harry P, Duah-Quashie Nancy O, Quashie Neils B
Abstract excerpt
The emergence and spread of Plasmodium falciparum resistance to current antimalarial drugs underscores the urgent need for new therapies with novel mechanisms of action and broad therapeutic potential. The purine salvage pathway in P. falciparum is a validated drug target and the import of purines into the parasite, mediated by Equilibrative Nucleoside Transporters (PfENTs), is a critical step in this pathway....
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