Article
Spontaneous mutations in the Plasmodium falciparum sarcoplasmic/ endoplasmic reticulum Ca2+-ATPase (PfATP6) gene among geographically widespread parasite populations unexposed to artemisinin-based combination therapies.
Antimicrobial agents and chemotherapy - 1 Jan 2011
Tanabe Kazuyuki, Zakeri Sedigheh, Palacpac Nirianne Marie Q, Afsharpad Manada, Randrianarivelojosia Milijaona, Kaneko Akira, Marma Aung Swi Prue, Horii Toshihiro, Mita Toshihiro
Abstract excerpt
Recent reports on the decline of the efficacy of artemisinin-based combination therapies (ACTs) indicate a serious threat to malaria control. The endoplasmic/sarcoplasmic reticulum Ca(2+)-ATPase ortholog of Plasmodium falciparum (PfSERCA) has been suggested to be the target of artemisinin and its derivatives. It is assumed that continuous artemisinin pressure will affect polymorphism of the PfSERCA gene (serca)...
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