Article
Association of microsatellite variations of Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene with reduced in vitro susceptibility to quinine: lack of confirmation in clinical isolates from Africa.
The American journal of tropical medicine and hygiene - 1 May 2010
Andriantsoanirina Valérie, Ménard Didier, Rabearimanana Stéphane, Hubert Véronique, Bouchier Christiane, Tichit Magali, Bras Jacques Le, Durand Rémy
Abstract excerpt
We sought to test the association of polymorphisms in Plasmodium falciparum nhe-1 (Pfnhe-1, gene PF13_0019) with in vitro susceptibility to quinine, which was previously reported in a limited number of reference strains or culture-adapted isolates. Determination of in vitro susceptibility to quinine, genotyping of Pfnhe-1 ms4760 microsatellite and polymorphism in codon 76 of Pfcrt were performed for 83 isolates...
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