In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene: the absence of association in clinical isolates from the Republic of Congo.

doi:10.1186/1475-2875-10-37

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Article

In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na+/H+ exchanger (Pfnhe-1) gene: the absence of association in clinical isolates from the Republic of Congo.

Malaria journal - 11 Feb 2011

Briolant Sébastien, Pelleau Stéphane, Bogreau Hervé, Hovette Philippe, Zettor Agnès, Castello Jacky, Baret Eric, Amalvict Rémy, Rogier Christophe, Pradines Bruno

Abstract excerpt

BACKGROUND: Quinine is still recommended as an effective therapy for severe cases of Plasmodium falciparum malaria, but the parasite has developed resistance to the drug in some cases. Investigations into the genetic basis for quinine resistance (QNR) suggest that QNR is complex and involves several genes, with either an additive or a pairwise effect. The results obtained when assessing one of these genes, the...

Topics

Amino Acid Sequence
Antimalarials
Chloroquine
Congo
Drug Resistance
Genotype
Humans
Inhibitory Concentration 50
Insect Proteins
Malaria, Falciparum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsatellite Repeats

Molecular Sequence Data

Parasitic Sensitivity Tests

Plasmodium falciparum

Polymorphism, Genetic

Protozoan Proteins

Quinine

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 21314947
DOI: 10.1186/1475-2875-10-37
PMCID: PMC3055222

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