Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels.

The Journal of clinical endocrinology and metabolism - 1 Dec 2007

Johansson Mattias, McKay James D, Wiklund Fredrik, Rinaldi Sabina, Verheus Martijn, van Gils Carla H, Hallmans Göran, Bälter Katarina, Adami Hans-Olov, Grönberg Henrik, Stattin Pär, Kaaks Rudolf

Abstract excerpt

BACKGROUND: Elevated levels of circulating IGF-I have consistently been associated with increased prostate cancer risk. We recently found a haplotype in the 3' region of the IGF-I gene associated with increased risk of prostate cancer, and we hypothesized that the observed association is mediated by circulating IGF-I. MATERIALS AND METHODS: We analyzed haplotypes and three haplotype-tagging single nucleotide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Heterozygote

Share to Insulin-Like Growth Factor I

Share to Logistic Models

Share to Prostatic Neoplasms

Share to Sweden

Source

Identifiers

PMID: 17911177
DOI: 10.1210/jc.2007-0887

Genes

CAPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels.PMID 17911177Read ↗

Comprehensive evaluation of genetic variation in the IGF1 gene and risk of prostate cancer.Semantic proximity Read ↗

Genetic and plasma variation of insulin-like growth factor binding proteins in relation to prostate cancer incidence and survival.Semantic proximity Read ↗

Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.Semantic proximity Read ↗

IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3).Semantic proximity Read ↗

Circulating insulin-like growth factor-I, total and free testosterone concentrations and prostate cancer risk in 200,000 men in UK BiobankSemantic proximity Read ↗

A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians.Semantic proximity Read ↗

Phenotypes and genotypes of insulin-like growth factor 1, IGF-binding protein-3 and cancer risk: evidence from 96 studies.Semantic proximity Read ↗

IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-Americans.Semantic proximity Read ↗

Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival.Semantic proximity Read ↗

Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort.Semantic proximity Read ↗

Insulin-like Growth Factor Pathway Genetic Polymorphisms, Circulating IGF1 and IGFBP3, and Prostate Cancer SurvivalSemantic proximity Read ↗

Interactions between genome-wide significant genetic variants and circulating concentrations of insulin-like growth factor 1, sex hormones, and binding proteins in relation to prostate cancer risk in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.