A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians.

doi:10.1093/hmg/ddq210

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A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians.

Human molecular genetics - 1 Aug 2010

Schumacher Fredrick R, Cheng Iona, Freedman Matthew L, Mucci Lorelei, Allen Naomi E, Pollak Michael N, Hayes Richard B, Stram Daniel O, Canzian Federico, Henderson Brian E, Hunter David J, Virtamo Jarmo, Manjer Jonas, Gaziano J Michael, Kolonel Laurence N, Tjønneland Anne, Albanes Demetrius, Calle Eugenia E, Giovannucci Edward, Crawford E David, Haiman Christopher A, Kraft Peter, Willett Walter C, Thun Michael J, Le Marchand Loïc, Kaaks Rudolf, Feigelson Heather Spencer, Bueno-de-Mesquita H Bas, Palli Domenico, Riboli Elio, Lund Eiliv, Amiano Pilar, Andriole Gerald, Dunning Alison M, Trichopoulos Dimitrios, Stampfer Meir J, Key Timothy J, Ma Jing

Abstract excerpt

The insulin-like growth factor (IGF) pathway has been implicated in prostate development and carcinogenesis. We conducted a comprehensive analysis, utilizing a resequencing and tagging single-nucleotide polymorphism (SNP) approach, between common genetic variation in the IGF1, IGF binding protein (BP) 1, and IGFBP3 genes with IGF-I and IGFBP-3 blood levels, and prostate cancer (PCa) risk, among Caucasians in the...

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PMID: 20484221
DOI: 10.1093/hmg/ddq210
PMCID: PMC2901143

Genes

IGF1
IGFBP3
IGFBP1
MAF

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