Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival.

doi:10.1093/jnci/dju085

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Article

Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival.

Journal of the National Cancer Institute - 1 Jun 2014

Cao Yin, Lindström Sara, Schumacher Fredrick, Stevens Victoria L, Albanes Demetrius, Berndt Sonja, Boeing Heiner, Bueno-de-Mesquita H Bas, Canzian Federico, Chamosa Saioa, Chanock Stephen J, Diver W Ryan, Gapstur Susan M, Gaziano J Michael, Giovannucci Edward L, Haiman Christopher A, Henderson Brian, Johansson Mattias, Le Marchand Loïc, Palli Domenico, Rosner Bernard, Siddiq Afshan, Stampfer Meir, Stram Daniel O, Tamimi Rulla, Travis Ruth C, Trichopoulos Dimitrios, Willett Walter C, Yeager Meredith, Kraft Peter, Hsing Ann W, Pollak Michael, Lin Xihong, Ma Jing

Abstract excerpt

BACKGROUND: The insulin-like growth factor (IGF) signaling pathway has been implicated in prostate cancer (PCa) initiation, but its role in progression remains unknown. METHODS: Among 5887 PCa patients (704 PCa deaths) of European ancestry from seven cohorts in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium, we conducted Cox kernel machine pathway analysis to evaluate whether 530...

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Identifiers

PMID: 24824313
DOI: 10.1093/jnci/dju085
PMCID: PMC4081624

Genes

IGF1
IGF2
IGFBP3
SSTR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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