IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-Americans.

doi:10.1093/carcin/bgm190

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IGF-1 and IGFBP-3 gene variants influence on serum levels and prostate cancer risk in African-Americans.

Carcinogenesis - 1 Oct 2007

Hernandez Wenndy, Grenade Cassandra, Santos Eunice R, Bonilla Carolina, Ahaghotu Chiledum, Kittles Rick A

Abstract excerpt

Insulin-like growth factor (IGF)-1 and Insulin-like growth factor binding protein-3 (IGFBP-3) are strong inhibitors of apoptosis and play a role in mediating the effects of growth hormone. Both IGF-1 and IGFBP-3 serum levels have been linked to cancer risk. Here, we explore the relationship between three common IGF polymorphisms [C/T single-nucleotide polymorphism (SNP) (rs7965399) and a dinucleotide repeat (CA)n...

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PMID: 17724372
DOI: 10.1093/carcin/bgm190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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