Article
Interactions between genome-wide significant genetic variants and circulating concentrations of insulin-like growth factor 1, sex hormones, and binding proteins in relation to prostate cancer risk in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
American journal of epidemiology - 1 May 2012
Tsilidis Konstantinos K, Travis Ruth C, Appleby Paul N, Allen Naomi E, Lindstrom Sara, Schumacher Fredrick R, Cox David, Hsing Ann W, Ma Jing, Severi Gianluca, Albanes Demetrius, Virtamo Jarmo, Boeing Heiner, Bueno-de-Mesquita H Bas, Johansson Mattias, Quirós J Ramón, Riboli Elio, Siddiq Afshan, Tjønneland Anne, Trichopoulos Dimitrios, Tumino Rosario, Gaziano J Michael, Giovannucci Edward, Hunter David J, Kraft Peter, Stampfer Meir J, Giles Graham G, Andriole Gerald L, Berndt Sonja I, Chanock Stephen J, Hayes Richard B, Key Timothy J
Abstract excerpt
Genome-wide association studies (GWAS) have identified many single nucleotide polymorphisms (SNPs) associated with prostate cancer risk. There is limited information on the mechanistic basis of these associations, particularly about whether they interact with circulating concentrations of growth factors and sex hormones, which may be important in prostate cancer etiology. Using conditional logistic regression,...
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