Article

Insulin-like Growth Factor Pathway Genetic Polymorphisms, Circulating IGF1 and IGFBP3, and Prostate Cancer Survival

2014-05-01

Abstract excerpt

BACKGROUND: The insulin-like growth factor (IGF) signaling pathway has been implicated in prostate cancer (PCa) initiation, but its role in progression remains unknown. METHODS: Among 5887 PCa patients (704 PCa deaths) of European ancestry from seven cohorts in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium, we conducted Cox kernel machine pathway analysis to evaluate whether 530 taggin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 62cfacda-0278-5ad1-a345-ed2a21344a87
DOI: 10.1093/jnci/dju218

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Insulin-like Growth Factor Pathway Genetic Polymorphisms, Circulating IGF1 and IGFBP3, and Prostate Cancer SurvivalDOI 10.1093/jnci/dju218Read

Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival.Semantic proximity Read

Common variants in IGF1 pathway genes and clinical outcomes after radical prostatectomy.Semantic proximity Read

A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians.Semantic proximity Read

Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.Semantic proximity Read

Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysisSemantic proximity Read

Genetic and plasma variation of insulin-like growth factor binding proteins in relation to prostate cancer incidence and survival.Semantic proximity Read

KLK3 SNP-SNP interactions for prediction of prostate cancer aggressiveness.Semantic proximity Read

Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases.Semantic proximity Read

Genetic polymorphisms in IGF-I and IGFBP-3 are associated with prostate cancer in the Chinese population.Semantic proximity Read

An expression signature at diagnosis to estimate prostate cancer patients’ overall survivalSemantic proximity Read

Insulin-like growth factor-1 genotypes and haplotypes influence the survival of prostate cancer patients with bone metastasis at initial diagnosis.Semantic proximity Read

Genetic Variants in Metabolic Signaling Pathways and Their Interaction with Lifestyle Factors on Breast Cancer Risk: A Random Survival Forest Analysis.Semantic proximity Read