IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3).

doi:10.1371/journal.pone.0002578

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Article

IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3).

PloS one - 2 Jul 2008

Patel Alpa V, Cheng Iona, Canzian Federico, Le Marchand Loïc, Thun Michael J, Berg Christine D, Buring Julie, Calle Eugenia E, Chanock Stephen, Clavel-Chapelon Francoise, Cox David G, Dorronsoro Miren, Dossus Laure, Haiman Christopher A, Hankinson Susan E, Henderson Brian E, Hoover Robert, Hunter David J, Kaaks Rudolf, Kolonel Laurence N, Kraft Peter, Linseisen Jakob, Lund Eiliv, Manjer Jonas, McCarty Catherine, Peeters Petra H M, Pike Malcolm C, Pollak Michael, Riboli Elio, Stram Daniel O, Tjonneland Anne, Travis Ruth C, Trichopoulos Dimitrios, Tumino Rosario, Yeager Meredith, Ziegler Regina G, Feigelson Heather Spencer

Abstract excerpt

IGF-1 has been shown to promote proliferation of normal epithelial breast cells, and the IGF pathway has also been linked to mammary carcinogenesis in animal models. We comprehensively examined the association between common genetic variation in the IGF1, IGFBP1, and IGFBP3 genes in relation to c...

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Identifiers

PMID: 18596909
DOI: 10.1371/journal.pone.0002578
PMCID: PMC2440354

Genes

IGF1
IGFBP3
IGFBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18596909-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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