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Article

Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort.

Journal of the National Cancer Institute - 18 Jan 2006

Cheng Iona, Stram Daniel O, Penney Kathryn L, Pike Malcolm, Le Marchand Loïc, Kolonel Laurence N, Hirschhorn Joel, Altshuler David, Henderson Brian E, Freedman Matthew L

Abstract excerpt

BACKGROUND: Insulin-like growth factor I (IGF-I) appears to play a role in prostate development and carcinogenesis. We investigated whether genetic variation at the IGF1 locus is associated with prostate cancer risk. METHODS: We sequenced IGF1 exons in germline DNA from 95 men with advanced prostate cancer to identify missense variants. IGF1 linkage disequilibrium patterns and common haplotypes were characterized...

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Identifiers

PMID: 16418515
DOI: 10.1093/jnci/djj013

Genes

IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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