Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential requirements for MCM proteins in DNA replication in Drosophila S2 cells.

PloS one - 5 Sept 2007

Crevel Gilles, Hashimoto Reina, Vass Sharron, Sherkow Jake, Yamaguchi Masamitsu, Heck Margarete M S, Cotterill Sue

Abstract excerpt

BACKGROUND: The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC components, we were interested in determining whether the entire cellular content was necessary for DNA replication in vivo. MET...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to DNA Replication
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to PCNA gene

Share to Mutation

Share to RNA Interference

Source

Open in PubMed Open full text

Identifiers

PMID: 17786205
DOI: 10.1371/journal.pone.0000833
PMCID: PMC1950684

Genes

MCM2
MCM8
MCM7
MCM5
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17786205-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential requirements for MCM proteins in DNA replication in Drosophila S2 cells.PMID 17786205Read ↗

Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant.Semantic proximity Read ↗

Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells.Semantic proximity Read ↗

Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression.Semantic proximity Read ↗

Multiple functions for Drosophila Mcm10 suggested through analysis of two Mcm10 mutant alleles.Semantic proximity Read ↗

The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding.Semantic proximity Read ↗

Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.Semantic proximity Read ↗

Mcm10 is required for oogenesis and early embryogenesis in Drosophila.Semantic proximity Read ↗

dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.Semantic proximity Read ↗

Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis.Semantic proximity Read ↗

Chromosomal Mcm2-7 distribution is the primary driver of the genome replication program in species from yeast to humansSemantic proximity Read ↗

Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.Semantic proximity Read ↗

Characterization of Schizosaccharomyces pombe mcm7(+) and cdc23(+) (MCM10) and interactions with replication checkpoints.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.