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Article

dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.

The EMBO journal - 1 Nov 1995

Feger G, Vaessin H, Su T T, Wolff E, Jan L Y, Jan Y N

Abstract excerpt

We have isolated the Drosophila disc proliferation abnormal (dpa) gene, a member of the MCM family of DNA replication factors. Members of this family of proteins are required for DNA replication in yeast. A dpa null mutant dies during pupal stages because imaginal tissues necessary for the formation of the adult fly fail to proliferate normally. Beginning in late embryogenesis BrdU labeling reveals DNA...

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Identifiers

PMID: 7489728
DOI: 10.1002/j.1460-2075.1995.tb00223.x
PMCID: PMC394648

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