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Article

dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.

The EMBO journal - 1 Nov 1995

Feger G, Vaessin H, Su T T, Wolff E, Jan L Y, Jan Y N

Abstract excerpt

We have isolated the Drosophila disc proliferation abnormal (dpa) gene, a member of the MCM family of DNA replication factors. Members of this family of proteins are required for DNA replication in yeast. A dpa null mutant dies during pupal stages because imaginal tissues necessary for the formation of the adult fly fail to proliferate normally. Beginning in late embryogenesis BrdU labeling reveals DNA...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Cycle Proteins
Cloning, Molecular
DNA Replication
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Fungal Proteins
Mitosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Sequence Alignment

Source

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Identifiers

PMID: 7489728
DOI: 10.1002/j.1460-2075.1995.tb00223.x
PMCID: PMC394648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7489728-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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